WASHINGTON — Dr. Anthony Fauci is back.

In truth, the nation’s leading infectious-diseases expert never really went away. But after enduring nearly a year of darts and undermining comments from former President Donald Trump, Fauci now speaks with the authority of the White House again.

He called it “liberating” Thursday to be backed by a science-friendly administration that has embraced his recommendations to battle COVID-19.

“One of the new things in this administration is, if you don’t know the answer, don’t guess,” Fauci said in one pointed observation during a White House briefing. “Just say you don’t know the answer.”

Fauci’s highly visible schedule on Thursday, the first full day of President Joe Biden’s term, underscored the new administration's confidence in the doctor but also the urgency of the moment.

His day began with a 4 a.m. virtual meeting with officials of the World Health Organization, which is based in Switzerland, and stretched past a 4 p.m. appearance at the lectern in the White House briefing room.

The breakneck pace showcased the urgent need to combat a pandemic that has killed more than 400,000 people in the United States and reached its deadliest phase just as the new president comes to office.

Fauci made clear that he believed the new administration would not trade in the mixed messages that so often came from the Trump White House, where scientific fact was often obscured by the president’s political agenda.

“The idea that you can get up here and talk about what you know and what the science is ... it is something of a liberating feeling,” Fauci told reporters. White House press secretary Jen Psaki had invited Fauci to take the podium first at her daily briefing.

Fauci acknowledged that it had been difficult at times to work for Trump. “It was very clear that there were things that were said, be it regarding things like hydroxychloroquine and other things, that really was uncomfortable because they were not based in scientific fact,” Fauci said.

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He added that he took “no pleasure” in having to contradict the president, a move that often drew Trump’s wrath.

Biden, during his presidential campaign, pledged to making Fauci his chief medical adviser when he took office, and the 80-year-old scientist was immediately in motion.

Fauci was up well before dawn Thursday for the virtual meeting with WHO, which Biden had rejoined the previous day after Trump withdrew the U.S. from the group out of anger over how it dealt with China in the early days of the pandemic. Fauci told the group that the United States would join its effort to deliver coronavirus vaccines to poor countries.

In the afternoon, the doctor stood alongside Biden and Vice President Kamala Harris in the White House as they unveiled a series of executive orders aimed at slowing the spread of the virus, which is killing more than 4,000 people a day in the U.S., as well as bolstering the nation’s sluggish vaccine distribution program.

Fauci had chatted amiably with reporters while awaiting the tardy new president. He acknowledged it was a long day and said that while he’d prefer to go for a run, he planned to powerwalk a few miles Thursday evening.

“There was clear political influence on the message of the pandemic. It became political to say that the pandemic was devastating our community because it was interpreted as a judgment on Trump,” said Dr. Nahid Bhadelia, an infectious-diseases physician and a professor at the Boston University School of Medicine. “It actively created enemies of the public health folks in a segment of the population.”

Having Fauci return to a central role, Bhadelia said, is a sign “that science was being repressed and now back.”

But Fauci, who has now served under seven presidents, persevered, telling friends that he would keep his head down and aim to outlast Trump.

“Clarity of message is the most important thing the government can be doing right now; the single biggest disservice Trump did was constantly telling people that pandemic was about to be over,” said Dr. Ashish Jha, dean of the Brown University School of Public Health, who has known Fauci for more than 20 years.

In his return to the briefing room, Fauci joked with reporters, seemingly far more relaxed than at any point last year. And as he stepped off the stage, Psaki said she’d soon have him back.